Differential adaptation of metabolic inflammation between primiparous and multiparous Zebu cows during transition period

This study aimed to estimate the changes in milk yield, fat, energy indicators [NEFA, BHBA, Dry MatterIntake (DMI) and Body Condition Score (BCS)] concentration of innate immune molecules (Haptoglobin: Hp,Serum Amyloid A: SAA, TLR-4, TNF-α, IL-1β, IL-6, IL-8), during transition period primiparous andmultiparous dual-purpose zebu (Deoni) cows. The blood sample was collected at weekly intervals pre-partum (-21±2, -14±1, -7±1, d), date calving (day 0), postpartum (3±1, 7±1, 14±1, 21±2 d) for estimationof above plasma variables using commercially available bovine specific ELISA kits. DMI BCS duringthe corresponding were also recorded. Data analyzed a linear mixed model considering group,time their interaction as fixed effects. Group, time had significant effect on whereprimiparous cows consumed higher early compared multiparous Groupalone fat per cent BHBA level while alone influenced BCS.The group effects TLR-4 IL-8 concentration. Group alsohad Hp TNF-α levels. It concluded that parity metabolicand where resulted more yield thanmultiparous indigenous